Staphylococcus saprophyticus morphology and culture
Staphylococcus saprophyticus (actually Staphylococcus saprophyticus subsp saprophyticus) belongs to the coagulase-negative staphylococci (CNS) of the Staphylococcus saprophyticus group. The normal habitat of the organisms is not fully understood. For some young women, the skin of the perineum and rectum are colonized with Staphylococcus saprophyticus.
Staphylococcus saprophyticus plays primarily as a causative agent of acute uncomplicated urinary tract infections in young women a role. In this group, Staphylococcus saprophyticus is the second most common pathogen in a proportion of 5-20% of all organisms by Escherichia coli. Infections occur mostly on post coitum.
Staphylococcus saprophyticus is also responsible for some of the non-specific urethritis in sexually active men. When symptoms are dysuric complaints in the foreground. Pathogenesis is significant that Staphylococcus saprophyticus is able to adhere to the epithelial cells of the urogenital tract. In some cases, it may lead to pyelonephritis. For complicated urinary tract infections it is usually regarded as a germ colonization. Nosocomial infections are practically non-existent.
Acute uncomplicated urinary tract infections in young women respond to short-term therapy over three days in general. As active ingredients are co-trimoxazole (EUSAPRIM others), trimethoprim (INFECTOTRIMET etc.) or quinolones of groups I and II, such as norfloxacin (BARAZAN, NORFLOHEXAL others), ciprofloxacin (Cipro URO, CIPRO Hexal, etc.) or ofloxacin (Tarivid, including OFLOHEXAL ) into consideration. The decline of the symptoms should be done under this therapy within 48 hours. Otherwise, a culture detection and further diagnostic measures are required. Once the treatment with the active substances was somewhat less effective than the short-term treatment for three days in the majority of studies.
|Mupirocin||Intranasally.||Apply to the affected area up to 3 times a day for 10 days.|
|Levofloxacin||250 - 750 mgs||once a day|
|Norfloxacin||400 mgs||twice a day for 7-14 days|
|Ciprofloxacin||500 mgs||twice a day for 7 - 14 days|
|Lomefloxacin||400 mgs (up to 600-800 mgs)||twice a day for 10 - 14 days|
|Cefpodoxime||100 - 200 mgs||twice a day for 10-14 days.|
|Cefepime||500 mgs - 1 g||twice a day for 7 - 10 days|
Staphylococcus saprophyticus diagnosis
An important feature of the species differentiation is the resistance to novobiocin. Novobiocin-susceptible strains belonging to the S. epidermidis group, novobiocin-resistant strains (minimum inhibitory concentration> 1.6 mg / L) for Staphylococcus saprophyticus group. Novobiocin is an inhibitor of gyrase, which is not approved as a human antibiotic in Germany.
Like other KNS Staphylococcus saprophyticus strains are often resistant to beta-lactam antibiotics. According to a European study Staphylococcus saprophyticus strains from patients with acute uncomplicated urinary tract infections are almost always sensitive to co-trimoxazole (EUSAPRIM others), trimethoprim (INFECTOTRIMET etc.) and quinolones.