Staphylococcus Saprophyticus morphology and culture
Staphylococcus saprophyticus (actually S. saprophyticus subspecies saprophyticus) belongs to the coagulase-negative Staphylococci (KNS) of the S. saprophyticus group. The normal habitat of organisms is not fully understood. In some young women, the skin of the perineum and the rectum are populated with S. saprophyticus.
Staphylococcus Saprophyticus diseases
Staphylococcus Saprophyticus plays a role primarily as an agent of acute uncomplicated urinary tract infections in young women. In this group, S. saprophyticus is the second most common pathogen in all organisms after Escherichia coli, with a content of 5-20%. Infections occur mostly postcoitum.
Staphylococcus Saprophyticus is also responsible for a portion of nonspecific urethritis in sexually active men. Symptoms are dysuric complaints. Pathogenically significant is that S. saprophyticus is able to adhere to the epithelial cells of the urogenital tract. In individual cases, pyelonephritis may occur. In the case of complicated urinary tract infections, it is generally regarded as a colonization nucleus. Nosocomial infections are virtually non-existent.
Acute uncomplicated urinary tract infections in young women generally refer to short-term therapy over three days. Ciprofloxacin (CIPROBAY URO, CIPROHEXAL, among others) or ofloxacin (TARIVID, OFLOHEXAL et al.) Can be used as active ingredients, such as cotrimoxazole (EUSAPRIM and others), trimethoprim (INFECTOTRIMET and others) or quinolones of groups I and II ). The decrease in symptoms should be done at least 48 hours after this therapy. Otherwise, cultivation and further diagnostic measures are required. In most studies, the treatment with the said active substances was somewhat less effective than the short-term therapy over three days. See ndrugs.com for medications.
|Linezolid||400 - 600 mgs||twice a day for 10-14 days ( enterococcal infections - 600 mgs for 14 - 28 days)|
|Levofloxacin||250 - 750 mgs||once a day|
|Ciprofloxacin||500 mgs||twice a day for 7 - 14 days|
An important feature of species differentiation is the resistance to novobiocin. Novobiocin-sensitive strains belong to the S. epidermidis group, novobiocin-resistant strains (minimum inhibitory concentration> 1.6 mg / l) to the S. saprophyticus group. Novobiocin is an inhibitor of gyrase, which is not approved as a human antibiotic in Germany.
Like other KNS, S. saprophyticus strains are often resistant to B-lactam antibiotics. According to data from a European-wide study, S. saprophyticus strains of patients with acute uncomplicated urinary tract infections are almost always sensitive to co-trimoxazole (EUSAPRIM et al.), Trimethoprim (INFECTOTRIMET et al.) And quinolones.